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Chemical Name: Conjugated Estrogens
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Premarin
Information
Premarin (C.E.S: Conjugated Estrogens) is a female hormone and is usually given to women who no longer produce the proper amount. Premarin is used to reduce menopause symptoms (e.g., hot flashes, vaginal dryness), to prevent bone loss (osteoporosis) in people at high risk, or to treat certain cancers in men and women (e.g., certain types of metastatic breast cancer).
Premarin may be used to treat other conditions as determined by your doctor. If you are only being treated for vaginal menopause symptoms, products applied locally such as vaginal creams, tablets, or rings should be considered before products taken by mouth or absorbed through the skin.
There are several medicines (e.g., raloxifene or bisphosphonates) that are safe and effective to prevent or treat bone loss. These medicines should be considered for use before estrogen therapy for osteoporosis. If you have other medical conditions as well, and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options. Estrogen-containing products should not be used to prevent heart disease.
Premarin
Directions
Follow the dosing schedule closely. This medicine may nbe taken with food or immediately after a meal to prevent stomach upset. GRAPEFRUIT OR GRAPEFRUIT JUICE may increase the amount of this medicine in your blood and cause side effects. Talk with your doctor or pharmacist before eating grapefruit or drinking grapefruit juice while you are taking this medicine.
STORE THIS MEDICINE at room temperature in a tightly-closed container, away from heat and light. Take this medicine regularly to receive the most benefit from it. Taking this medicine at the same time each day will help you to remember. Continue to take this medicine even if you feel well.
Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once
Premarin
Side Effects
Premarin side effects, that may go away during treatment, include dizziness, lightheadedness, headache, stomach upset, bloating, nausea, weight changes, increased/decreased interest in sex, or breast tenderness. Contact your doctor immediately if you continue to experience Premarin side effects such as mental/mood changes (e.g., severe depression, memory loss), calf pain/swelling, sudden severe headache, chest pain, trouble breathing, one-sided weakness, slurred speech, vision changes (e.g., change in contact lens fit, loss of vision) breast lumps, swelling of hands or feet, changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, or prolonged bleeding), unusual vaginal discharge/itching/odor, or yellowing of eyes or skin.
Premarin side effects are unlikely but seek immediate medical attention if Premarin side effects occur. Symptoms of Premarin side effects include rash, itching, swelling, severe dizziness, or trouble breathing. If you notice other Premarin side effects not listed above, contact your doctor, nurse, or pharmacist.
WARNING: Premarin side effects have been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause, especially in women with a uterus who receive estrogen-only hormone therapy. Premarin side effects may also increase the risk of cancer of the ovary or breast. Estrogen-containing products should not be used to prevent heart disease. Estrogen given in combination with another hormone (progestin) for replacement therapy can infrequently cause Premarin side effects like heart disease (e.g., heart attacks), stroke, serious blood clots (pulmonary embolism and deep venous thrombosis), dementia, and cancer of the breast. These risks appear to depend on the length of time this medicine is used and the amount of estrogen per dose.
Therefore, this medicine should be used for the shortest possible length of time at the lowest effective dose, so you obtain the benefits and minimize the chance of serious Premarin side effects from long-term treatment. Consult your doctor/pharmacist for details.
Premarin
Precautions
If you use this medicine for an extended period, you should be evaluated at least once a year. This medicine is not effective in preventing or treating a tendency toward miscarriages nor the threat of miscarriage. This medicine must not be used during pregnancy because its use may result in Premarin side effects like birth defects or cancer later in the child's life. Some medicines or medical conditions may interact with this medicine and lead to Premarin side effects.
INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. Additional monitoring of your dose or condition may be needed if you are taking corticosteroids (e.g., prednisone); hydantoins (e.g., phenytoin); warfarin; or any medicines that affect certain liver enzymes (CYP450-3A4), such as azole antifungals (e.g., ketoconazole, itraconazole), carbamazepine, macrolide antibiotics (e.g., clarithromycin, erythromycin), phenobarbital, rifamycins (e.g., rifampin), ritonavir, cimetidine, or St. John's wort.
DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other Premarin side effects including a family medical history (especially breast lumps/cancer), asthma, diabetes, seizures, migraine headaches, heart disease (e.g., high blood pressure, heart attacks, congestive heart failure), kidney disease, low thyroid hormone (hypothyroidism), abnormal calcium level in the blood, depression, high blood pressure during pregnancy (toxemia), yellowing of eyes/skin (cholestatic jaundice) during pregnancy or with past estrogen use, womb problems (e.g., uterine fibroids, endometriosis), cholesterol/lipid problems, gallbladder disease, excessive weight gain, certain blood disorder (porphyria), any allergies, pregnancy, or breast-feeding.
Use of this medicine is not recommended if you have undiagnosed abnormal vaginal bleeding, cancer (e.g., breast cancer), blood clots, liver disease, or active/recent stroke or heart attack.
The generic alternative is not manufactured by the company that makes the brand product.
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